Asthma
This is the story of Prof. Bart Lambrecht and how a seemingly crazy idea kickstarted a journey to develop a potential treatment for asthma and airway inflammation. It’s a story about a passion for science, and collaboration between academia and biotech.
The VIB Center for Inflammation Research in Ghent is mainly studying inflammatory diseases. Asthma is one of the diseases that is very close to Prof. Lambrecht’s heart. It is also a very common disease affecting about 8 to 10% of people.
Finding the crystals
The Charcot-Leyden crystals played an important role in the discovery process. “We knew, that in this disease, proteins which are normally in a soluble state, can crystallize. And these protein crystals are known as Charcot Leyden crystals.“
This had been known for 150 years but nobody had focused this aspect of the disease until the partnership between Prof. Lambrecht’s team at VIB and argenx. “We have unraveled what these crystals are doing. We found that the crystals are made in the airway of severe asthmatics and that most of the people that you see in the clinic already have sticky mucus with Charcot-Leyden crystals in them.”
The search for antibodies
To accelerate the discovery process Prof. Lambrecht was looking for antibody engineering expertise: “We had some experience already with argenx, in developing antibodies. They have a very efficient platform to generate antibodies.”
Initially, the goal was just to neutralize the target protein, Galectin-10, which is the build-up of Charcot-Leyden crystals. But beyond expectations, the team demonstrated that the antibodies were able to dissolve existing crystals as well by attacking the component protein.
“A crystal that can stay in patients for years, that is super stable. Then you design an antibody that is attacking that protein.”