Neurology
Myasthenia Gravis (MG)
Our Commitment to Patients
Each day at argenx, we are motivated to pursue a better tomorrow alongside patients. We aim to do this through partnership because we know that "together we are better". As your ally, we pioneer innovations to advance the understanding of rare diseases; we want to deliver immunology treatments to patients worldwide.
We listen to patients, supporters and advocacy communities; we hear your stories and share your determination.
We integrate your aspirations into how we innovate, how we conduct research and design trials, and how we can support you in the daily struggles you face living with a rare disease.
There is a common purpose across argenx that is driven by your resilience and we welcome this opportunity to be with you on this journey.
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Learn more about the symptoms and diagnosis
of these conditions
"When I started receiving treatment, it was hard for me not knowing when I would lose my motor functions, or even what tomorrow might bring."
- Mihoko, Living with MG
Neurology
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
"At first I was kind of like, what is that? What is CIDP? I've never heard of that. But then, the relief set in more than confusion…because at least there was a name to what I had."
- Jamilah, Living with CIDP
Hematology
Immune Thrombocytopenia (ITP)
"I still struggle with fatigue but continue to work, and I'm fortunate to have understanding colleagues, so I can take care of myself."
- Dina, Living with ITP
Discover more about other diseases in our pipeline
Neurology
Multifocal Motor Neuropathy (MMN)
MMN is a rare but serious chronic disorder that affects the nerves responsible for controlling muscle movement, mainly in the hands, forearms, and lower legs. Over time, it causes progressive muscle weakness that could eventually lead to considerable disability. This may cause irreversible functional impairment and fatigue, often impacting a person’s physical health, psychological health, social life, and occupation.
Seronegative Generalized Myasthenia Gravis (gMG)
gMG results in the immune system mistakenly attacking the nerve-muscle connection. People living with the condition experience symptoms such as muscle weakness, fatigue, or difficulty with muscle control, which can be debilitating and potentially life-threatening. AChR-antibody seronegative generalized myasthenia gravis (AChRAb- gMG) is a subgroup of gMG. Approximately 20% of people with gMG are AChRAb- gMG, a patient population that includes MuSK-Ab, LRP4-Ab, and gMG patients with no identifiable antibodies.
Ocular Myasthenia Gravis (oMG)
oMG primarily affects the muscles responsible for eye movement and control. Common symptoms include double vision (diplopia), drooping of the eyelids (ptosis), and difficulty in maintaining a steady gaze. Approximately 50-60% of individuals with MG initially experience ocular symptoms before the disease progresses to involve other muscles.
Congenital Myasthenic Syndromes (CMS)
CMS are a clinically and genetically heterogeneous group of disorders that typically present with muscle weakness in the first decade of life, but often are either undiagnosed for prolonged periods, or misdiagnosed with other conditions, most commonly seronegative myasthenia gravis.
Amyotrophic Lateral Sclerosis (ALS)
ALS is a rare disease that causes the connections between the muscles and nerves to break down over time. This results in muscle loss and weakness, leading to an inability to walk, speak, and breathe. ALS is eventually fatal, and the cause is not known.
Spinal Muscular Atrophy (SMA)
SMA is a rare genetic neuromuscular disorder caused by deletions or mutations in the SMN1 gene, leading to reduced SMN protein levels. This results in motor neuron degeneration, causing muscle weakness and wasting. SMA can lead to difficulties with movement, breathing, and swallowing.
Endocrinology
Graves’ Disease
Graves’ disease is an autoimmune disorder that affects the thyroid, a small gland located at the front of the neck that regulates the body’s metabolism, heart rate, and temperature. In Graves’ disease, the immune system mistakenly attacks the thyroid, causing it to produce too much thyroid hormones. The excess thyroid hormones can cause a variety of symptoms including weight loss, a fast or irregular heartbeat, feeling nervous or anxious, increased sweating, and other general signs of an overactive metabolism. Some people with Graves’ disease also have bulging eyes.
Rheumatology
Myositis (IIM)
IIM is the name for a group of rare, severe autoimmune disorders mediated by autoantibodies and characterized by chronic muscle inflammation, muscle weakness, pain, and impaired quality of life. Myositis subsets mediated by autoantibodies include immune-mediated necrotizing myopathy (IMNM), anti-synthetase syndrome (ASyS), and dermatomyositis (DM).
Sjogren’s Disease (SjD)
Primary SjD occurs when the body’s immune system mistakenly attacks its own glands, leading to symptoms such as dry eyes and dry mouth. People often experience severe fatigue, pain, and complications affecting other organs. It can also increase the risk of developing a type of cancer that starts in the body’s immune system.
Systemic Sclerosis (SSc)
SSc is a rare disease that affects the skin, which becomes thick and tight. It can also affect other organs, such as the lungs, heart, kidneys, and digestive system. This happens because the immune system, which is supposed to protect the body, starts attacking its own tissue. The extent and severity of the impact varies among individuals depending on the organs involved and the progression of the disease. Living with SSc can significantly impact a person’s life, in terms of their physical and psychological health, social life, and occupation.
Nephrology
Delayed Graft Function (DGF)
DGF occurs when the new kidney takes longer to start working after receiving a kidney transplant. This can happen due to factors such as how long the quality was outside the body, its quality, potential rejection, or underlying health issues. If not appropriately treated and kidney function does not improve, the transplant may not be successful, and a new kidney may be needed.
Antibody Mediated Rejection (AMR)
AMR is a disease in which a transplanted kidney gets recognized by the recipient’s immune system as foreign and, as a result, undergoes rejection. This rejection can lead to kidney damage, which results in loss of function of the organ. This may lead to organ loss and patients being put on the transplant waiting list again.
